Drug treatment of migraine: Part II. Preventive therapy.

In most cases, successful preventive therapy for migraines requires daily medication for months or years. Perimenstrual use of a preventive agent is a common exception. Preventive therapy is usually undertaken in patients who have more than two headache episodes per month or those very much disabled by headaches. Beta blockers are usually the first choice for preventive therapy, and amitriptyline is also commonly used. Despite widespread use of calcium channel blockers for prevention of migraine, their benefits are controversial. Although effective for prevention of migraine, methysergide and phenelzine are usually relegated to last-resort use because of potentially serious side effects. The migraine patient who is refractory to standard preventive therapy may have rebound headache related to overuse of abortive migraine medications, or concomitant psychopathology.
AuthorsS L Noble, K L Moore
JournalAmerican family physician (Am Fam Physician) Vol. 56 Issue 9 Pg. 2279-86 (Dec 1997) ISSN: 0002-838X [Print] United States
PMID9402813 (Publication Type: Journal Article, Review)
Chemical References
  • Adrenergic beta-Antagonists
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Antidepressive Agents
  • Calcium Channel Blockers
  • Serotonin Antagonists
  • Adrenergic beta-Antagonists (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Anticonvulsants (therapeutic use)
  • Antidepressive Agents (therapeutic use)
  • Calcium Channel Blockers (therapeutic use)
  • Humans
  • Migraine Disorders (drug therapy, prevention & control)
  • Patient Selection
  • Recurrence
  • Risk Factors
  • Serotonin Antagonists (therapeutic use)

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