The effects of hange-shashin-to on gastric function in comparison with sho-saiko-to.

Abstract

The effects of "Hange-shashin-to (TJ-14)" on gastric function were examined in comparison with "Sho-saiko-to (TJ-9)". Oral treatment with TJ-14 (125-500 mg/kg) caused dose-dependent suppression of ethanol-induced gastric injury, while it did not suppress gastric lesions induced by water-immersion stress. TJ-9 (125-500 mg/kg, p.o.) suppressed both water-immersion stress-induced gastric lesions and ethanol-induced gastric injury in a dose-dependent manner. Intraduodenal administration of TJ-14 even at 500 mg/kg did not affect gastric juice secretion, while TJ-9 at 125 to 500 mg/kg dose-dependently suppressed gastric juice secretion. TJ-14 (125-500 mg/kg, p.o.) accelerated gastric emptying in normal rats and improved the delayed gastric emptying induced by BaCl2 in a dose-dependent manner, whereas such effect was not noted with TJ-9. Oral treatment with TJ-14 at 500 mg/kg significantly suppressed apomorphine-induced vomiting, but it did not affect copper sulfate-induced vomiting. These results suggest that TJ-14 exhibits an anti-ulcer action (probably based on its ability to protect the gastric mucosa), improvement of gastric emptying and an anti-emetic action. TJ-9 also showed anti-ulcer effects, probably based on its ability to suppress gastric secretion and to protect the gastric mucosa. Thus, the present study demonstrated the effectiveness of TJ-14 and TJ-9 against gastric disease, and provided basic data which explain the differences in clinical application between these two kampo medicines.

• Authors: Y Kase, M Yuzurihara, S Iizuka, A Ishige, Y Komatsu
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 20 Issue 11 Pg. 1155-9 (Nov 1997) ISSN: 0918-6158 [Print] Japan
• PMID: 9401723 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Chinese Herbal
• hange-shashinto
• Ethanol
• saiko-keishi-to
• Copper Sulfate
• Apomorphine

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Apomorphine (adverse effects)
• Copper Sulfate (adverse effects)
• Drugs, Chinese Herbal (pharmacology)
• Ethanol (toxicity)
• Ferrets
• Gastric Emptying (drug effects)
• Gastric Juice (metabolism)
• Male
• Medicine, Chinese Traditional
• Rats
• Rats, Wistar
• Stomach (drug effects, pathology, physiology)
• Vomiting (chemically induced, prevention & control)