Abstract | OBJECTIVES: METHODS: A prospective study was made of 57 patients with ED (mean age 46 +/- 16 years, 72% males). At endoscopy, biopsies from gastric antrum and body were obtained for histological study (haematoxylin and eosin). A 13C-urea breath test was also performed. Omeprazole 20 mg twice daily plus two antibiotics ( amoxycillin 1 g twice daily, clarithromycin 500 mg twice daily, metronidazole 500 mg twice daily) were administered for 1 week. Endoscopy and breath test were repeated 1 month after completing therapy, and the breath test was performed again at 6 months. RESULTS: All patients were H. pylori positive. Overall eradication was achieved in 86% (95% CI 75-93%). Duodenal erosion healing was obtained in 45 patients (79%). Healing was achieved in 86% (CI 73-93%) of cases with successful eradication therapy, but only in 3/8 (37%; CI 8.5-75%) patients with therapy failure (P < 0.01). In the multivariate analysis, H. pylori eradication was the only variable which correlated with erosion healing (odds ratio 10; CI 2-51; P < 0.01). Histological improvement, in both the gastric antrum and body, was demonstrated when eradication was achieved (P < 0.001). Six months after diagnosis H. pylori absence was confirmed in all patients with initial therapy success (all of them asymptomatic), and infection was confirmed in the eight patients who were H. pylori positive after therapy (six of them symptomatic). At 6-month follow-up, endoscopy was normal in 6/7 H. pylori-negative patients with previously persistent ED, while erosions were still present in 4/5 H. pylori-positive patients with previously persistent ED. CONCLUSION:
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Authors | J P Gisbert, D Boixeda, C M de Argila, F Bermejo, C Redondo, L de Rafael |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 9
Issue 10
Pg. 957-62
(Oct 1997)
ISSN: 0954-691X [Print] England |
PMID | 9391784
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Omeprazole
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
- Anti-Ulcer Agents
(therapeutic use)
- Drug Therapy, Combination
(therapeutic use)
- Duodenitis
(diagnosis, drug therapy, microbiology)
- Female
- Helicobacter Infections
(complications, diagnosis, drug therapy)
- Helicobacter pylori
- Humans
- Logistic Models
- Male
- Middle Aged
- Omeprazole
(therapeutic use)
- Prevalence
- Prospective Studies
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