Abstract |
1 The protective effects of the intracerebroventicular (i.c.v.) administration of the H1-receptor antagonist, mepyramine and the H2-receptor antagonists, burimamide and metiamide on centrally induced histamine- emesis were studied in unanaesthetized dogs. 2 The PD50 values of intraventricular mepyramine, burimamide and metiamide against the 100% emetic dose of histamine (3.0 mg i.c.v.) were found to be approximately 200 mug, 20 mug and 20 mug respectively. 3 Although burimamide (i.c.v. or i.v.) afforded protection against histamine-induced emesis, there was no protection against intravenous apomorphine-or oral copper sulphate-induced emesis. 4 The results suggest that both H1- and H2-histamine receptors in the emetic chemoreceptor trigger zone of the area postrema are concerned in histamine-induced emesis.
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Authors | K P Bhargava, K S Dixit, G Palit |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 57
Issue 2
Pg. 211-3
(Jun 1976)
ISSN: 0007-1188 [Print] England |
PMID | 938795
(Publication Type: Journal Article)
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Chemical References |
- Emetics
- Receptors, Drug
- Metiamide
- Histamine
- Pyrilamine
- Burimamide
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Topics |
- Animals
- Burimamide
(pharmacology)
- Chemoreceptor Cells
(physiology)
- Dogs
- Emetics
(pharmacology)
- Female
- Histamine
(administration & dosage, pharmacology, physiology)
- Injections, Intraventricular
- Male
- Metiamide
(pharmacology)
- Pyrilamine
(pharmacology)
- Receptors, Drug
(drug effects)
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