HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Nature of histamine receptors in the emetic chemoreceptor trigger zone.

Abstract
1 The protective effects of the intracerebroventicular (i.c.v.) administration of the H1-receptor antagonist, mepyramine and the H2-receptor antagonists, burimamide and metiamide on centrally induced histamine-emesis were studied in unanaesthetized dogs. 2 The PD50 values of intraventricular mepyramine, burimamide and metiamide against the 100% emetic dose of histamine (3.0 mg i.c.v.) were found to be approximately 200 mug, 20 mug and 20 mug respectively. 3 Although burimamide (i.c.v. or i.v.) afforded protection against histamine-induced emesis, there was no protection against intravenous apomorphine-or oral copper sulphate-induced emesis. 4 The results suggest that both H1- and H2-histamine receptors in the emetic chemoreceptor trigger zone of the area postrema are concerned in histamine-induced emesis.
AuthorsK P Bhargava, K S Dixit, G Palit
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 57 Issue 2 Pg. 211-3 (Jun 1976) ISSN: 0007-1188 [Print] England
PMID938795 (Publication Type: Journal Article)
Chemical References
  • Emetics
  • Receptors, Drug
  • Metiamide
  • Histamine
  • Pyrilamine
  • Burimamide
Topics
  • Animals
  • Burimamide (pharmacology)
  • Chemoreceptor Cells (physiology)
  • Dogs
  • Emetics (pharmacology)
  • Female
  • Histamine (administration & dosage, pharmacology, physiology)
  • Injections, Intraventricular
  • Male
  • Metiamide (pharmacology)
  • Pyrilamine (pharmacology)
  • Receptors, Drug (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: