[The change of hepatic energy status after transcatheter arterial embolization (TAE) for hepatocellular carcinoma--a study using 31P-MRS].

Abstract

In six patients with hepatocellular carcinoma, adenosine triphosphate (ATP) phosphomonoester (PME), phosphoric acid (Pi) and pH were measured before and after transcatheter arterial embolization (TAE), using 31P-magnetic resonance spectroscopy (MRS). The effectiveness of TAE was judged by the extent of lipiodol accumulation within the tumor and change in serum alphafetoprotein level. The pH within the tumor decreased 2-9 days after TAE in all the cases, and beta ATP/Pi ratio decreased when TAE was effective, whereas the ratio did not decrease when TAE was ineffective. The beta ATP/Pi ratio measured by 31P-MRS seems to be a useful, non-invasive marker of the anti-tumor effect of TAE, although further investigation is needed.

• Authors: K Taniguchi, T Kaminaga, M Sakon, K Umeshita, T Yamada, Y Takeda, N Higaki, T Aoki, H Ohzato, Y Hasuike, M Gotoh, T Murakami, H Nakamura, M Monden
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 24 Issue 12 Pg. 1632-4 (Sep 1997) ISSN: 0385-0684 [Print] Japan
• PMID: 9382494 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phosphates
• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (metabolism)
• Aged
• Carcinoma, Hepatocellular (metabolism, therapy)
• Embolization, Therapeutic (methods)
• Energy Metabolism
• Hepatic Artery
• Humans
• Hydrogen-Ion Concentration
• Liver (metabolism)
• Liver Neoplasms (metabolism, therapy)
• Magnetic Resonance Spectroscopy
• Male
• Phosphates (metabolism)