Feingold syndrome: report of a new family and review.

Abstract

Feingold syndrome (or oculodigitoesophagoduodenal syndrome; Microcephaly, Mesobrachyphalangy, Tracheo-esophageal fistula syndrome) is a dominantly inherited combination of hand and foot abnormalities, microcephaly, esophageal/duodenal atresia, short palpebral fissures and learning disabilities, first reported in 1975 (MIM 164280). We report on the seventh family with Feingold syndrome. The propositus is a male infant with esophageal and duodenal atresia, brachymesophalangy of the fifth fingers, bilateral syndactyly of toes 4-5 (and 2-3), relative microcephaly, and facial anomalies. His mother also has microcephaly, similar facial appearance, short fifth fingers with single flexion crease, syndactyly of toes 4-5, and learning disabilities. The maternal sister, brother, and grandmother of the propositus have the same phenotype. The 7 families with Feingold syndrome are reviewed. Intestinal (esophageal/duodenal) atresia/obstruction occurs in approximately 1/3 of the patients with Feingold syndrome.

• Authors: W Courtens, S Levi, F Verbelen, A Verloes, E Vamos
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 73 Issue 1 Pg. 55-60 (Nov 28 1997) ISSN: 0148-7299 [Print] United States
• PMID: 9375923 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Abnormalities, Multiple (genetics, physiopathology)
• Adult
• Duodenal Diseases (genetics)
• Esophageal Atresia (genetics)
• Face (abnormalities)
• Female
• Foot Deformities, Congenital (genetics)
• Hand Deformities, Congenital (diagnostic imaging, genetics)
• Humans
• Infant, Newborn
• Male
• Pedigree
• Radiography
• Syndrome