Abstract | BACKGROUND: PROCEDURE: Nine consecutive children with diffuse pontine gliomas were treated on this single arm study. Carboplatin, given in combination with fixed dose etoposide, was escalated in successive cohorts to determine its maximum tolerated systemic exposure (AUC). Outcome was coded based on imaging characteristics and clinical status. RESULTS: Eight of the nine children on this study died of their disease at a median of 44 weeks, essentially the same survival as those treated on a previous Pediatric Oncology Group study using hyperfractionated radiation therapy alone. Toxicity was almost exclusively hematologic and not associated with significant morbidity. CONCLUSIONS:
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Authors | A W Walter, A Gajjar, J S Ochs, J W Langston, R A Sanford, L E Kun, R Heideman |
Journal | Medical and pediatric oncology
(Med Pediatr Oncol)
Vol. 30
Issue 1
Pg. 28-33
(Jan 1998)
ISSN: 0098-1532 [Print] United States |
PMID | 9371386
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Etoposide
- Carboplatin
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Topics |
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brain Neoplasms
(drug therapy, pathology, radiotherapy)
- Carboplatin
(administration & dosage)
- Chemotherapy, Adjuvant
- Child
- Child, Preschool
- Dose Fractionation, Radiation
- Drug Administration Schedule
- Etoposide
(administration & dosage)
- Female
- Glioma
(drug therapy, pathology, radiotherapy)
- Humans
- Male
- Pons
- Radiotherapy, Adjuvant
- Treatment Outcome
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