Abstract |
Extracellular recordings were made in the dorsal respiratory group (DRG) and adjacent reticular formation following single- shock stimulation of the anterior ethmoidal nerve (AEN) and during sneeze evoked by repetitive stimulation of the AEN in nembutal-anaesthetized, curarized and ventilated cats. These neurones were characterised according to (i) their activity during the respiratory cycle (as inspiratory augmenting or decrementing (I Aug or I Dec), expiratory augmenting or decrementing (E Aug or E Dec), silent or tonic), and (ii) their axonal projection (bulbospinal or non-bulbospinal-non-vagal (BS or NBS-NV)). Following single- shock stimulation of the AEN, most of the inspiratory neurones were transiently inhibited, whereas E Aug neurones were activated and E Dec neurones were activated and then inhibited. Silent neurones responded with a multispike or a paucispike pattern. Following repetitive stimulation of the AEN and during the resulting sneeze reflex, I Aug neurones increased their activity in parallel with the phrenic activity, I Dec neurones fired at the onset and at the end of the inspiration, E Dec and some silent neurones fired either during the compressive phase or after the expulsive phase, whereas E Aug and some silent neurones fired during the expulsive phase. We conclude that sneeze involves a reconfiguration of the central respiratory drive which uses, at least partly, the respiratory network to trigger a non-ventilatory defensive motor act.
|
Authors | F Wallois, L Bodineau, J M Macron, D Marlot, B Duron |
Journal | Brain research
(Brain Res)
Vol. 768
Issue 1-2
Pg. 71-85
(Sep 12 1997)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 9369303
(Publication Type: Journal Article)
|
Topics |
- Animals
- Cats
- Electric Stimulation
- Female
- Male
- Neurons
(physiology)
- Phrenic Nerve
(physiology)
- Reflex
(physiology)
- Respiratory System
(innervation)
- Sneezing
(physiology)
- Solitary Nucleus
(cytology, physiology)
- Spinal Cord
(cytology, physiology)
- Vagus Nerve
(physiology)
|