Abstract | STUDY OBJECTIVE: DESIGN: Prospective, randomized, controlled study. SETTING: Twenty-six-bed pediatric ICU in a tertiary children's hospital. PATIENTS: INTERVENTIONS: Twelve patients were treated with 10 ppm inhaled nitric oxide from the onset of randomization and 12 control patients were initially maintained on a regimen of conventional therapy alone. After a period of 24 h, control patients were also treated with 10 ppm inhaled nitric oxide. Hemodynamic and blood gas measurements were performed at baseline, at 1 h after randomization, and at 24-h intervals for 2 days. MEASUREMENTS AND RESULTS: Inhaled nitric oxide decreased the ratio of pulmonary to systemic vascular resistance and improved oxygenation indexes during the initial hour following randomization. However, 24 h after randomization, the oxygenation indexes of 11 surviving treated patients were not improved in comparison to baseline or the oxygenation indexes of 10 surviving control patients. Oxygenation indexes acutely improved in control patients when inhaled nitric oxide was started after 24 h of conventional therapy. Oxygenation indexes remained improved in the initial control patients after 24 h of inhaled nitric oxide. CONCLUSIONS:
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Authors | R W Day, E M Allen, M K Witte |
Journal | Chest
(Chest)
Vol. 112
Issue 5
Pg. 1324-31
(Nov 05 1997)
ISSN: 0012-3692 [Print] United States |
PMID | 9367476
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acute Disease
- Administration, Inhalation
- Blood Gas Analysis
- Child
- Child, Preschool
- Double-Blind Method
- High-Frequency Ventilation
(methods)
- Humans
- Hypoxia
(drug therapy, mortality, physiopathology)
- Infant
- Infant, Newborn
- Nitric Oxide
(administration & dosage, therapeutic use)
- Positive-Pressure Respiration
(methods)
- Prospective Studies
- Pulmonary Circulation
(drug effects)
- Pulmonary Wedge Pressure
- Respiratory Insufficiency
(drug therapy, mortality, physiopathology)
- Survival Rate
- Vascular Resistance
(drug effects)
- Ventricular Pressure
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