Abstract | BACKGROUND: METHODS: In this study, the authors describe three patients with PSML. The clinical, histologic, and immunohistochemical features of the lymphomas were studied. Clonal immunoglobulin heavy chain gene rearrangement was investigated by polymerase chain reaction. RESULTS: All three cases of PSML were detected by imaging studies performed in routine follow-up of cases of chronic liver disease associated with HCV infection. Macronodular lesions were found in the three spleens; two of them were of normal weight and another was moderately enlarged. The former two were the smallest PSMLs reported to date. The histology was B-cell NHL in all cases. All 3 patients were alive after splenectomy with an average follow-up of 51.7 months (range, 35-74 months). CONCLUSIONS: HCV infection may play an etiologic role in the development of splenic B-cell lymphoma. The long survival of the patients in this study may have been due to early splenectomy.
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Authors | T Satoh, T Yamada, S Nakano, O Tokunaga, S Kuramochi, T Kanai, H Ishikawa, T Ogihara |
Journal | Cancer
(Cancer)
Vol. 80
Issue 10
Pg. 1981-8
(Nov 15 1997)
ISSN: 0008-543X [Print] United States |
PMID | 9366302
(Publication Type: Case Reports, Journal Article)
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Topics |
- Aged
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Hepatitis C, Chronic
(complications)
- Humans
- Lymphoma, Large B-Cell, Diffuse
(complications, genetics, pathology)
- Male
- Middle Aged
- Polymerase Chain Reaction
- Spleen
(pathology)
- Splenic Neoplasms
(complications, genetics, pathology)
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