Abstract |
Gastroesophageal reflux (GER) occurs in 22-66% of patients with noncardiac chest pain (NCCP). Although open-label investigations have shown beneficial effects of antireflux therapy in NCCP, no double-blind, prospective, placebo-controlled studies have been conducted. The purpose of this study was to evaluate the effects of omeprazole compared to placebo in a prospective, double-blind, randomized trial of patients with NCCP and GER. Thirty-six consecutive patients with NCCP and GER documented by 24-hr ambulatory pH testing entered this study. The subjects were randomized to omeprazole, 20 mg by mouth twice a day (17 patients), or placebo (19 patients) for eight weeks. Patients on omeprazole obtained significantly more improvement in the fraction of chest pain days (P = 0.006) and severity (P = 0.032) when compared to placebo. More patients in the omeprazole group reported improvement in individual daily pain scores (81% vs 44%, P = 0.03) and individual severity scores (81% vs 50%, P = 0.057). Thirteen (81%) of the subjects in the treatment arm reported overall symptomatic improvement versus one (6%) in the placebo group (P = 0.001). The results of this study indicate that acid suppression with omeprazole effectively improves chest pain in patients with NCCP and GER.
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Authors | S R Achem, B E Kolts, T MacMath, J Richter, D Mohr, L Burton, D O Castell |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 42
Issue 10
Pg. 2138-45
(Oct 1997)
ISSN: 0163-2116 [Print] United States |
PMID | 9365149
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- Proton Pump Inhibitors
- Omeprazole
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Topics |
- Chest Pain
(drug therapy, physiopathology)
- Double-Blind Method
- Esophagus
(drug effects, physiopathology)
- Female
- Follow-Up Studies
- Gastric Acidity Determination
- Gastroesophageal Reflux
(drug therapy, physiopathology)
- Humans
- Hydrogen-Ion Concentration
- Male
- Middle Aged
- Omeprazole
(therapeutic use)
- Peristalsis
(drug effects)
- Placebos
- Prospective Studies
- Proton Pump Inhibitors
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