Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats.

Abstract

1 The effect of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated Panpal, and antidotal treatment (the oxime HI-6 plus benactyzine) in soman poisoning was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activity in diaphragm and various brain parts. 3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acetylcholinesterase activity in all brain parts studied. 4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreatment or antidotal treatment alone. 5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman-poisoned rats without significant reactivation of brain acetylcholinesterase.

• Authors: J Kassa, J Fusek
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 16 Issue 10 Pg. 563-9 (Oct 1997) ISSN: 0960-3271 [Print] England
• PMID: 9363473 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antidotes
• Chemical Warfare Agents
• Cholinesterase Inhibitors
• Cholinesterase Reactivators
• Oximes
• Pyridinium Compounds
• Benactyzine
• Trihexyphenidyl
• Soman
• Acetylcholinesterase
• asoxime chloride
• Pyridostigmine Bromide

Topics

• Acetylcholinesterase (metabolism)
• Animals
• Antidotes (therapeutic use)
• Benactyzine (administration & dosage, therapeutic use)
• Blood Pressure (drug effects)
• Brain (enzymology)
• Central Nervous System Diseases (chemically induced, drug therapy)
• Chemical Warfare Agents (toxicity)
• Cholinesterase Inhibitors (toxicity)
• Cholinesterase Reactivators (therapeutic use)
• Diaphragm (enzymology)
• Drug Therapy, Combination
• Electrocardiography
• Heart Rate (drug effects)
• Male
• Oximes
• Pyridinium Compounds (therapeutic use)
• Pyridostigmine Bromide (administration & dosage)
• Rats
• Rats, Wistar
• Respiration (drug effects)
• Soman (toxicity)
• Trihexyphenidyl (administration & dosage)