The mechanism of action of methotrexate.

Because of methotrexate's well-documented efficacy in the treatment of rheumatoid arthritis, it is important that we understand the mechanism of action of this drug. There are two biochemical mechanisms by which methotrexate may modulate inflammation: (1) promotion of adenosine release and (2) inhibition of transmethylation reactions. Evidence is reviewed that favors the notion that the endogenous anti-inflammatory autocoid adenosine mediates the anti-inflammatory effects of methotrexate. This insight should aid in the design of new agents for the treatment of rheumatoid arthritis and other inflammatory diseases.
AuthorsB N Cronstein
JournalRheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 23 Issue 4 Pg. 739-55 (Nov 1997) ISSN: 0889-857X [Print] UNITED STATES
PMID9361153 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents
  • Antirheumatic Agents
  • Enzyme Inhibitors
  • Folic Acid Antagonists
  • Adenosine
  • Methotrexate
  • Adenosine (pharmacology)
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Antirheumatic Agents (metabolism, pharmacology)
  • Arthritis, Rheumatoid (drug therapy)
  • Enzyme Inhibitors
  • Folic Acid Antagonists (pharmacology)
  • Humans
  • Methotrexate (metabolism, pharmacology)
  • Methylation

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