Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig.

Abstract

Intraperitoneal injection of 60 mg/kg of pentylenetetrazole (PTZ) induced seizure in rats, but was subthreshold and did not result in seizure in guinea pigs. Three days after intracerebroventricular (i.c.v.) injection of 75 micrograms 6-hydroxydopamine (6-OHDA) in guinea pigs, PTZ induced seizures similar to those seen in rats. In both rats and 6-OHDA-treated guinea pigs, i.c.v. injection of melanin-concentrating hormone (MCH) 15 min before PTZ prevented seizure activity. These results suggest that MCH-containing neurons may participate in the neural circuits involved in expression of PTZ-induced seizure.

• Authors: K M Knigge, J E Wagner
• Journal: Peptides (Peptides) Vol. 18 Issue 7 Pg. 1095-7 ( 1997) ISSN: 0196-9781 [Print] United States
• PMID: 9357072 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Convulsants
• Hypothalamic Hormones
• Melanins
• Pituitary Hormones
• melanin-concentrating hormone
• Oxidopamine
• Pentylenetetrazole

Topics

• Animals
• Convulsants (toxicity)
• Female
• Guinea Pigs
• Hypothalamic Hormones (pharmacology, physiology)
• Male
• Melanins (pharmacology, physiology)
• Neurons (physiology)
• Oxidopamine (toxicity)
• Pentylenetetrazole (toxicity)
• Pituitary Hormones (pharmacology, physiology)
• Rats
• Rats, Sprague-Dawley
• Seizures (etiology, physiopathology)
• Species Specificity