Therapeutic activity of pretazettine, a narcissus alkaloid on Rauscher leukemia: comparison with tazettine and streptonigrin.

Abstract

The therapeutic activity of narcissus alkaloid pretazettine HC1 (PTZ) on established Rauscher leukemia has been demonstrated and compared with the isomer tazettine (TZ) and an antibiotic, streptonigrin (SN). PTZ and SN showed remarkable prolongation effect on the life span of the leukemic mice and the antiviral activity has been confirmed in mouse 3T3 cells infected with Rauscher virus. TZ showed no significant activity in the leukemic mice and was inhibitory to the virus growth in the cells at much higher doses than PTZ. It is suggested that the stereochemical rearrangement from PTZ to TZ inactivates the biological activity of PTZ.

• Authors: E Furusawa, S Furusawa, J Y Lee, S Patanavanich
• Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (Proc Soc Exp Biol Med) Vol. 152 Issue 2 Pg. 186-91 (Jun 1976) ISSN: 0037-9727 [Print] United States
• PMID: 935182 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Amaryllidaceae Alkaloids
• pretazettine
• Streptonigrin
• tazettine

Topics

• Alkaloids (pharmacology, therapeutic use)
• Amaryllidaceae Alkaloids
• Animals
• Cell Line
• Female
• Leukemia, Experimental (drug therapy)
• Male
• Mice
• Mice, Inbred BALB C
• Plants, Medicinal
• Rauscher Virus (drug effects)
• Streptonigrin (pharmacology, therapeutic use)
• Structure-Activity Relationship