Effect of cytochalasin D on systemic and local anaphylaxis in a murine model.

Abstract

We investigated the effect of cytochalasin D on anaphylaxis. Cytochalasin D dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in rats. Especially, cytochalasin D inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 1 microg g-1 body weight (BW). Cytochalasin D significantly inhibited serum histamine levels induced by compound 48/80. Cytochalasin D (10(-1) microg g-1 BW) also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE to 79.6+/-1.8%. Cytochalasin D dose-dependently inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. The level of cAMP in rat peritoneal mast cells, when cytochalasin D was added, transiently and significantly increased about fourfold compared with that of basal cells. Our studies provide evidence that cytochalasin D will be beneficial in the treatment of anaphylaxis.

• Authors: H Y Shin, E H Lee, T Y Shin, H M Kim
• Journal: Pharmacological research (Pharmacol Res) Vol. 36 Issue 2 Pg. 141-6 (Aug 1997) ISSN: 1043-6618 [Print] Netherlands
• PMID: 9344643 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 1997 The Italian Pharmacological Society.

Chemical References

• Anti-Asthmatic Agents
• Nucleic Acid Synthesis Inhibitors
• Cytochalasin D
• Immunoglobulin E
• p-Methoxy-N-methylphenethylamine
• Cyclic AMP
• Cromolyn Sodium

Topics

• Anaphylaxis (chemically induced, prevention & control)
• Animals
• Anti-Asthmatic Agents (therapeutic use)
• Cromolyn Sodium (therapeutic use)
• Cyclic AMP (metabolism)
• Cytochalasin D (therapeutic use)
• Histamine Release (drug effects)
• Immunoglobulin E
• Mast Cells (drug effects, metabolism)
• Nucleic Acid Synthesis Inhibitors (therapeutic use)
• Passive Cutaneous Anaphylaxis (drug effects)
• Rats
• Rats, Wistar
• p-Methoxy-N-methylphenethylamine