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The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice.

Abstract
The Insulin Receptor (IR) is a potential oncogene for mammary epithelial cells since its content is increased in most human breast cancer specimens, and both ligand-dependent malignant transformation and ligand-dependent enhanced growth occurs in cultured breast cells overexpressing the IR. To better understand whether the IR plays a role in mammary carcinogenesis which is independent of other initiation factors, we measured IR content in transgenic mouse models of breast cancer induced by 3 known oncogenes (Wnt-1, Neu, and Ret). Insulin receptor content was measured by a specific radioimmunoassay. In normal mammary gland tissues IR content was 14.6 +/- 1.4 ng/mg of protein (mean +/- SEM, n = 6). In the 3 cancers IR content was elevated (Neu = 36.1 +/- 4.6, n = 8, p < 0.002; Wnt-1 = 38.3 +/- 2.6, n = 13, p < 0.001; and Ret = 53.6 +/- 7.1, n = 7, p < 0.001). These data indicate that IR overexpression, in addition to being a potential oncogene, is increased in mouse tumors initiated by other oncogenes, and therefore may also play a supportive role in the growth of breast cancers.
AuthorsL Frittitta, A Cerrato, M G Sacco, N Weidner, I D Goldfine, R Vigneri
JournalBreast cancer research and treatment (Breast Cancer Res Treat) Vol. 45 Issue 2 Pg. 141-7 (Sep 1997) ISSN: 0167-6806 [Print] Netherlands
PMID9342439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Receptor, Insulin
Topics
  • Animals
  • Female
  • Male
  • Mammary Glands, Animal (chemistry)
  • Mammary Neoplasms, Animal (chemistry, genetics, pathology)
  • Mice
  • Mice, Transgenic
  • Oncogenes (genetics)
  • Radioimmunoassay
  • Receptor, Insulin (analysis)

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