Abstract |
This study examined rates of concomitant structural and chromosomal abnormalities in 14 fetuses with a diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age, compared to 14 fetuses with a diagnosis of Dandy-Walker malformation or variant between 21 weeks' gestation and delivery. A total of 24 fetuses had Dandy-Walker malformation and four had Dandy-Walker variant. Eight of the fetuses with the malformation had ventriculomegaly: one of the fetuses with early diagnosis and seven with later diagnosis (p = 0.027). None of the fetuses with Dandy-Walker variant had ventriculomegaly. The overall prevalence of concomitant structural abnormalities was 13/28; 8/14 for fetuses with early prenatal diagnosis and 5/14 for fetuses with late prenatal diagnosis of the malformation or the variant. Chromosomal abnormality rates were significantly higher among fetuses with early prenatal diagnosis (7/14) than among those with later prenatal diagnosis (1/14; p = 0.032). Abnormal karyotypes were more prevalent among fetuses without ventriculomegaly (7/20), compared to fetuses with ventriculomegaly (1/8). We conclude that fetuses with an antenatal diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age have worse prognosis than fetuses with a later prenatal diagnosis of the same defect.
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Authors | B Ulm, M R Ulm, J Deutinger, G Bernaschek |
Journal | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
(Ultrasound Obstet Gynecol)
Vol. 10
Issue 3
Pg. 167-70
(Sep 1997)
ISSN: 0960-7692 [Print] England |
PMID | 9339523
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Chromosome Aberrations
(diagnostic imaging)
- Chromosome Disorders
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 18
- Confidence Intervals
- Dandy-Walker Syndrome
(diagnostic imaging)
- Diagnosis, Differential
- Female
- Fetal Death
(epidemiology)
- Fetal Diseases
(diagnostic imaging)
- Gestational Age
- Humans
- Infant, Newborn
- Intracranial Arteriovenous Malformations
(diagnostic imaging)
- Pregnancy
- Pregnancy Outcome
- Retrospective Studies
- Sensitivity and Specificity
- Trisomy
- Ultrasonography, Prenatal
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