Abstract | BACKGROUND: METHODS: The serum concentrations of IgG1, IgG2, IgG3, IgG4, IgA, IgM, IgD and IgE, and the frequency of the G2m(23) allotype were measured by enzyme immunoassay in 15 patients with CDGS type I. RESULTS: Ten (67%) patients had an elevated level of at least one Ig, when compared to age-related reference ranges. No particular isotype was involved although a tendency towards high IgE levels was registered. The frequency of homozygous G2m(23)-negative CDGS patients (33%) was not different from that of blood donors (34%). CONCLUSION: We conclude that CDGS I patients have no major changes in the serum levels of any specific Ig isotype. The severe infections observed in some CDGS patients are therefore unlikely to involve any Ig deficiency. Our results do not exclude that Ig of patients with CDGS may have altered physiological functions because of abnormal glycosylation.
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Authors | J E Björklund, H Stibler, B Kristiansson, S G Johansson, C G Magnusson |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 114
Issue 2
Pg. 116-9
(Oct 1997)
ISSN: 1018-2438 [Print] Switzerland |
PMID | 9338604
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycoproteins
- Immunoglobulin Allotypes
- Immunoglobulin Isotypes
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Congenital Disorders of Glycosylation
(classification, epidemiology, immunology)
- Female
- Glycoproteins
(blood)
- Humans
- Immunoglobulin Allotypes
(blood)
- Immunoglobulin Isotypes
(blood)
- Infant
- Male
- Middle Aged
- Reference Values
- Sweden
(epidemiology)
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