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Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1.

Abstract
A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement-mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis. Anti-GM1 antibodies might have directly caused the axonal neuropathy by binding to GM1 or cross-reactive antigens in the nerves.
AuthorsM Hirayama, T Hamano, M Shiratori, T Mutoh, T Kumano, T Aita, M Kuriyama
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 151 Issue 1 Pg. 23-4 (Oct 03 1997) ISSN: 0022-510X [Print] Netherlands
PMID9335005 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies
  • G(M1) Ganglioside
Topics
  • Acanthocytes (immunology)
  • Adult
  • Antibodies (analysis)
  • Axons (pathology)
  • Chorea (immunology)
  • Enzyme-Linked Immunosorbent Assay
  • G(M1) Ganglioside (immunology)
  • Humans
  • Male
  • Neuromuscular Diseases (immunology, pathology)

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