Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats.

Abstract	We investigated the effect of sodium tauroursodeoxycholate (UR-906) on cholestasis in common bile duct-ligated rats in comparison with the effect of dehydrocholic acid. UR-906 (30-180 mumol/kg) and dehydrocholic acid (180 mumol/kg) were intravenously given once daily for consecutive 20 days in rats and the common bile duct was ligated for the last 10 days. On the next day after the last test drug administration, serum biochemical and plasma hemostatic variables were determined. UR-906 significantly ameliorated the elevation of serum cholesterol, phospholipid, bilirubin and bile acid concentrations in bile duct-ligated rats. UR-906 significantly suppressed the prolongation of plasma prothrombin time and activated partial thromboplastin time. Furthermore, UR-906 significantly suppressed the decreases in plasma coagulation factor II and X activities. However, dehydrocholic acid did not cause significant changes in any of the variables examined in this model. These results suggest that UR-906 has a beneficial effect against cholestasis induced by bile duct ligation in rats and that this drug may be useful in the treatment of clinical cholestatic disorders.
Authors	K Ishizaki, S Kinbara, N Miyazawa, Y Takeuchi, N Hirabayashi, H Kasai, T Araki
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 333 Issue 2-3 Pg. 207-13 (Aug 27 1997) ISSN: 0014-2999 [Print] Netherlands
PMID	9314037 (Publication Type: Comparative Study, Journal Article)
Chemical References	Bile Acids and Salts Cholagogues and Choleretics Phospholipids Taurochenodeoxycholic Acid ursodoxicoltaurine Prothrombin Factor X Cholesterol Dehydrocholic Acid Bilirubin
Topics	Animals Bile Acids and Salts (blood) Bile Ducts (physiopathology, surgery) Bilirubin (blood) Cholagogues and Choleretics (pharmacology) Cholestasis (drug therapy, physiopathology) Cholesterol (blood) Dehydrocholic Acid (pharmacology) Disease Models, Animal Factor X (analysis) Hemostasis (drug effects) Ligation Male Partial Thromboplastin Time Phospholipids (blood) Prothrombin (analysis) Prothrombin Time Rats Rats, Wistar Taurochenodeoxycholic Acid (pharmacology)

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