[Cost-effectiveness analysis of preventive treatment of urinary lithiasis recurrence using potassium citrate].

Abstract

OBJECTIVE:

This study evaluated two possible alternatives of potassium citrate administration-granulate (liquid) and tablet (wax matrix)-versus treatment with diet and/or fluid to prevent recurrence of urinary lithiasis.

METHODS:

The cost-effectiveness of the alternative modalities were analyzed using data from the studies conducted by Barceló (1993), Pak (1985) and Preminger (1985). The variables utilized for effectiveness were 'avoided relapse' and 'avoided intervention'. Since the data from the foregoing studies did not make any distinction between the two alternative forms of potassium citrate administration, the incidence of side effects and the dropout rate were included. These data were obtained from the studies conducted by Barceló (1993). Campoy (1994) and Conte (1994).

RESULTS/CONCLUSION:

Potassium citrate is effective in the prevention of recurrence of urinary lithiasis; relapses and interventions were significantly avoided. Both forms of potassium citrate are similarly effective and the only differences found were in regard to the side effects and the dropout rate; however, further studies are warranted to determine the possible differences with more precision. Potassium citrate in granulated form in much more cost-effective than the diet and fluid regimen than the tablet alternative, with a difference significantly in favor of the former in the order of 8:1. Price was the most important variable and therefore it is important to determine the appropriate dosage since it will influence the cost-effectiveness ratio and the allocation of resources.

• Authors: R Gisbert Gelonch, L Fernández Augusto
• Journal: Archivos espanoles de urologia (Arch Esp Urol) Vol. 50 Issue 4 Pg. 373-80 (May 1997) ISSN: 0004-0614 [Print] Spain
• Vernacular Title: Análisis coste-efectividad del tratamiento preventivo de recidivas de litiasis urinaria con citrato potásico.
• PMID: 9313046 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)

Chemical References

• Solutions
• Tablets
• Potassium Citrate

Topics

• Clinical Trials as Topic
• Combined Modality Therapy
• Cost-Benefit Analysis
• Drug Costs
• Drug Evaluation
• Humans
• Patient Compliance
• Potassium Citrate (administration & dosage, adverse effects, economics, therapeutic use)
• Recurrence
• Solutions
• Spain (epidemiology)
• Tablets
• Urinary Calculi (diet therapy, drug therapy, economics, epidemiology, prevention & control)