Mucosal interleukin-1 beta production and acid secretion in enlarged fold gastritis.

Abstract

BACKGROUND:

We have previously shown that eradication of Helicobacter pylori increases acid secretion in H. pylori-associated enlarged fold gastritis.

AIM:

To investigate whether locally produced interleukin-1 beta is possibly involved in the inhibition of acid secretion in H. pylori gastritis.

METHODS:

IL-1 beta release from the gastric body mucosa was determined by short-term culture of biopsy specimens in 13 patients with enlarged fold gastritis (all H. pylori-positive), five H. pylori-positive and 10 H. pylori-negative patients without enlarged folds. The acid-inhibitory effect of locally produced IL-1 beta was examined by [14C]-aminopyrine uptake assay using isolated rabbit gastric glands.

RESULTS:

IL-1 beta release was significantly greater in patients with enlarged fold gastritis, significantly correlated with both basal and tetragastrin-stimulated acid outputs in the H. pylori-positive patients (r = -0.591 and r = -0.641, respectively; P < 0.01), and significantly decreased with concomitant increases in acid secretions after eradication of H. pylori. [14C]-aminopyrine uptake was inhibited by IL-1 beta in a dose-dependent manner.

CONCLUSIONS:

Increased production of IL-1 beta caused by H. pylori infection is possibly involved in the inhibition of acid secretion in enlarged fold gastritis.

• Authors: Y Yasunaga, Y Shinomura, S Kanayama, Y Higashimoto, M Yabu, Y Miyazaki, Y Murayama, H Nishibayashi, S Kitamura, Y Matsuzawa
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 11 Issue 4 Pg. 801-9 (Aug 1997) ISSN: 0269-2813 [Print] England
• PMID: 9305492 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gastrins
• Interleukin-1
• Aminopyrine

Topics

• Adult
• Aged
• Aminopyrine (metabolism)
• Animals
• Female
• Gastric Acid (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Gastrins (blood)
• Gastritis, Hypertrophic (metabolism, pathology)
• Helicobacter Infections (metabolism)
• Helicobacter pylori
• Humans
• Interleukin-1 (biosynthesis, pharmacology)
• Male
• Middle Aged
• Rabbits
• Stomach (pathology)