Abstract | AIM: To evaluate whether the immunoexpression of c-erbB-2 and p53 is involved in the pathogenesis and progression of salivary tumours with myoepithelial differentiation. METHODS: RESULTS: CONCLUSIONS: The c-erbB-2 and p53 proteins are not involved in the pathogenesis of pleomorphic adenoma and myoepithelioma and do not constitute biomarkers in assessing the risk of recurrence. c-erbB-2 is not involved in the genesis of low grade salivary neoplasia with myoepithelial differentiation. The percentage of this type of neoplasia with p53 accumulation is low (10%) and does not appear to be related to tumour recurrence.
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Authors | J C Rosa, A Félix, I Fonseca, J Soares |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 50
Issue 8
Pg. 661-3
(Aug 1997)
ISSN: 0021-9746 [Print] England |
PMID | 9301549
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neoplasm Proteins
- Tumor Suppressor Protein p53
- Receptor, ErbB-2
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Topics |
- Adenocarcinoma
(metabolism)
- Adenoma, Pleomorphic
(metabolism)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Myoepithelioma
(metabolism)
- Neoplasm Proteins
(metabolism)
- Neoplasm Recurrence, Local
(metabolism)
- Receptor, ErbB-2
(metabolism)
- Salivary Gland Neoplasms
(metabolism)
- Tumor Suppressor Protein p53
(metabolism)
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