Scaling lichenoid eruptions and Sjögren-like syndrome: manifestations of nonfatal postoperative transfusion-associated graft-versus-host disease?

Abstract

We report a case of an 81-year-old woman in whom lichenoid eruptions and Sjögren-like sicca syndrome developed 45 days after cholecystectomy. During surgery, one unit (130 ml) of unirradiated packed red blood cells from a male donor was transfused. The lichenoid eruptions cleared up with exfoliation: however, sicca symptoms remained during the follow-up period of four years. Histological examinations of both skin and lip biopsy specimens were in agreement with those of graft-versus-host disease (GVHD). A Y-chromosomal body was identified in the lymphocytes in the skin lesion by staining with quinacrine dihydrochloride and in the lip lesion by a method with in situ hybridization. The findings suggest that this case demonstrated the manifestations of non-fatal transfusion-associated GVHD.

• Authors: R Tanei, T Yamamoto, H Yokono, T Motoori
• Journal: The Journal of dermatology (J Dermatol) Vol. 24 Issue 8 Pg. 514-21 (Aug 1997) ISSN: 0385-2407 [Print] England
• PMID: 9301145 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA Antigens

Topics

• Aged
• Aged, 80 and over
• Biopsy, Needle
• Cholecystectomy
• Diagnosis, Differential
• Female
• Graft vs Host Disease (diagnosis, etiology, physiopathology)
• HLA Antigens (analysis)
• Humans
• Lichenoid Eruptions (diagnosis, etiology, physiopathology)
• Male
• Sjogren's Syndrome (diagnosis, etiology, physiopathology)
• Transfusion Reaction