Hypothermic effects of neuropeptide FF analogues in mice.

Abstract

The effects of neuropeptide FF (NPFF) and its analogues on mouse body temperature were examined. In a thermoneutral environment, administration of NPFF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2), 1DMe ([D.Tyr1, (N.Me)Phe3] NPFF), and 3D ([D.Tyr1, D.Leu2, D.Phe3] NPFF) in the third ventricle produced marked hypothermia. The effect of 1DMe was dose-dependent, and 45 nmol decreased body temperature by 5.6 degrees C. This effect was more pronounced when mice were placed at 4 degrees C. Hypothermia was not reversed by naloxone, an opioid antagonist, and was not modified by morphine. After 5 days of chronic treatment with 1DMe, mice did not became tolerant to the hypothermic effect. These results indicate that central NPFF receptors may control body temperature independently from opioid functions.

• Authors: C Desprat, J M Zajac
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 58 Issue 2 Pg. 559-63 (Oct 1997) ISSN: 0091-3057 [Print] United States
• PMID: 9300619 (Publication Type: Journal Article)

Chemical References

• Narcotic Antagonists
• Oligopeptides
• neuropeptide FF, Tyr(1)-N-methyl-Phe(3)-
• phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide

Topics

• Animals
• Body Temperature (drug effects)
• Female
• Hypothermia (chemically induced)
• Male
• Mice
• Narcotic Antagonists (pharmacology)
• Oligopeptides (pharmacology)