Abstract | OBJECTIVE: DESIGN: Prospective randomised study. SETTING: Teaching hospital, Turkey. SUBJECTS: 200 patients aged between 1 and 16 years treated from December 1991 to December 1995 who were randomly assigned to one of four groups each consisting of 50 patients. INTERVENTIONS: Preoperative antibiotics given intravenously, peritoneal drainage by Penrose drains without irrigation, appendicectomy with the inversion of the stump by a purse string, taking peritoneal swabs, and primary skin closure. MAIN OUTCOME MEASURES: Comparability of the groups, duration of fever, leucocytosis, antibiotic treatment, stay in hospital, nasogastric intubation, and drainage, as well as results of cultures and complications. RESULTS: There were no significant differences between the groups for any variable studied. The predominant bacterial species were Escherichia coli, Klebsiella spp, Pseudomonas spp, Fusobacteria, and Peptostreptococci which were appropriately covered by all the antibiotic regimens. Fourteen patients had complications including wound infections (n = 10), prolonged ileus (n = 2) and intra-abdominal abscess (n = 2) all of which were treated conservatively. There was no mortality and no major complications. All regimens had the same clinical and bacteriological efficacy. CONCLUSION:
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Authors | A O Ciftci, F C Tanyel, N Büyükpamukçu, A Hiçsonmez |
Journal | The European journal of surgery = Acta chirurgica
(Eur J Surg)
Vol. 163
Issue 8
Pg. 591-6
(Aug 1997)
ISSN: 1102-4151 [Print] England |
PMID | 9298911
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amebicides
- Anti-Bacterial Agents
- Cephalosporins
- Penicillins
- Clindamycin
- Ornidazole
- Ceftriaxone
- Tobramycin
- Piperacillin
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Topics |
- Adolescent
- Amebicides
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Appendicitis
(drug therapy, surgery)
- Ceftriaxone
(therapeutic use)
- Cephalosporins
(therapeutic use)
- Child
- Child, Preschool
- Clindamycin
(therapeutic use)
- Drug Therapy, Combination
(therapeutic use)
- Female
- Humans
- Injections, Intravenous
- Intestinal Perforation
(drug therapy, surgery)
- Male
- Ornidazole
(therapeutic use)
- Penicillins
(therapeutic use)
- Piperacillin
(therapeutic use)
- Prospective Studies
- Rupture, Spontaneous
- Tobramycin
(therapeutic use)
- Treatment Outcome
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