Colocalization of somatostatin- and HLA-DR-like immunoreactivity in dendritic cells of psoriatic skin.

Abstract

This study presents an immunohistochemical characterization of somatostatin-positive dendritic cells in psoriatic lesions. Somatostatin is a neuropeptide with inhibitory action on several neuropeptides and hormones, but also with immunomodulating properties, and has been used in several studies as treatment for psoriasis. The number of somatostatin-positive dendritic cells was found to be larger in psoriatic lesions than in normal skin of psoriasis patients and healthy controls. Colocalization of somatostatin and HLA-DR immunoreactivity was demonstrated in a subgroup of dendritic cells of psoriatic skin, whereas double-labelled cells were not found in uninvolved skin. The somatostatin-positive cells in the epidermis and dermis did not co-express CD1a, CD35, CD45RB, CD45RO, CD68, factor XIIIa or S-100. On the basis of these findings, the somatostatin-positive cells seem to represent a specific population of dermal dendritic cells, distinct from Langerhans' cells and factor XIIIa-positive cells, which are found in elevated amounts in chronic plaque psoriasis.

• Authors: T Talme, M Schultzberg, K G Sundqvist, J A Marcusson
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 77 Issue 5 Pg. 338-42 (Sep 1997) ISSN: 0001-5555 [Print] Sweden
• PMID: 9298123 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR Antigens
• Hormone Antagonists
• Somatostatin

Topics

• Adult
• Aged
• Analysis of Variance
• Biopsy (methods)
• Cells, Cultured
• Dendritic Cells (chemistry)
• Double-Blind Method
• Female
• HLA-DR Antigens (analysis)
• Hormone Antagonists (analysis)
• Humans
• Immunohistochemistry (methods)
• Male
• Middle Aged
• Psoriasis (pathology)
• Skin (chemistry)
• Somatostatin (analysis)