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Bradykinin-induced venodilation is not different in blacks.

AbstractAIMS:
The aim of this study was to determine whether young, normotensive blacks who have been recently demonstrated to have a venodilator response to isoprenaline decreased compared with whites, also have an decreased vasodilatory response to bradykinin.
METHODS:
Eleven black and 11 white subjects were studied. Full dose-response curves to bradykinin (dosing range 0.5-500 ng min-1) were generated in hand veins preconstricted with phenylephrine (dosing range 20-6800 ng min-1).
RESULTS:
The groups had a similar maximal response to bradykinin (57.6 +/- 32.2% vs 67.8 +/- 49.3%, P = NS 95% confidence interval for the difference (CI): -47.3, 26.8). Also, the log of the dose that produced half maximal response to bradykinin was similar for the two groups (0.89 +/- 0.58 vs 0.78 +/- 0.61 ng min-1, P = NS, 95% CI: -0.42, 0.64). There was no difference between the two groups in the log dose of phenylephrine necessary to produce 80% constriction of the hand vein.
CONCLUSION:
Diminished vasodilatory response to endothelium-derived relaxing factor (EDRF) does not seem to be associated with the increased prevalence of hypertension in blacks.
AuthorsZ Vajo, M McDonald, B Takahashi, H Zafar, K Srivathsan, W D Dachman
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 44 Issue 3 Pg. 285-8 (Sep 1997) ISSN: 0306-5251 [Print] England
PMID9296324 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Vasodilator Agents
  • Phenylephrine
  • Bradykinin
Topics
  • Adult
  • Black People
  • Bradykinin (pharmacology)
  • Female
  • Hand (blood supply)
  • Humans
  • Male
  • Phenylephrine (pharmacology)
  • Vasodilation
  • Vasodilator Agents (pharmacology)
  • Veins (drug effects, physiology)
  • White People

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