Abstract | AIMS: The aim of this study was to determine whether young, normotensive blacks who have been recently demonstrated to have a venodilator response to isoprenaline decreased compared with whites, also have an decreased vasodilatory response to bradykinin. METHODS: Eleven black and 11 white subjects were studied. Full dose-response curves to bradykinin (dosing range 0.5-500 ng min-1) were generated in hand veins preconstricted with phenylephrine (dosing range 20-6800 ng min-1). RESULTS: The groups had a similar maximal response to bradykinin (57.6 +/- 32.2% vs 67.8 +/- 49.3%, P = NS 95% confidence interval for the difference (CI): -47.3, 26.8). Also, the log of the dose that produced half maximal response to bradykinin was similar for the two groups (0.89 +/- 0.58 vs 0.78 +/- 0.61 ng min-1, P = NS, 95% CI: -0.42, 0.64). There was no difference between the two groups in the log dose of phenylephrine necessary to produce 80% constriction of the hand vein. CONCLUSION:
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Authors | Z Vajo, M McDonald, B Takahashi, H Zafar, K Srivathsan, W D Dachman |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 44
Issue 3
Pg. 285-8
(Sep 1997)
ISSN: 0306-5251 [Print] England |
PMID | 9296324
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Vasodilator Agents
- Phenylephrine
- Bradykinin
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Topics |
- Adult
- Black People
- Bradykinin
(pharmacology)
- Female
- Hand
(blood supply)
- Humans
- Male
- Phenylephrine
(pharmacology)
- Vasodilation
- Vasodilator Agents
(pharmacology)
- Veins
(drug effects, physiology)
- White People
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