Simultaneous occurrence of papulonecrotic tuberculide and erythema induratum and the identification of Mycobacterium tuberculosis DNA by polymerase chain reaction.

Abstract

The simultaneous occurrence of two tuberculides in one patient is rare. We report the case of a 32-year-old man presenting with both papulonecrotic tuberculide and erythema induratum. Mycobacterial DNA was identified from both skin lesions by polymerase chain reaction using formalin-fixed and paraffin-embedded tissues, suggesting that tuberculides are related to tuberculosis. New skin lesions developed after the patient discontinued his medication on his own initiative, 2 months after triple antituberculous therapy had been started. It is important to continue therapy for a prolonged period.

• Authors: Y H Chuang, T T Kuo, C M Wang, C N Wang, W R Wong, H L Chan
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 137 Issue 2 Pg. 276-81 (Aug 1997) ISSN: 0007-0963 [Print] England
• PMID: 9292081 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• DNA, Bacterial

Topics

• Adult
• DNA, Bacterial (analysis)
• Erythema Induratum (complications, microbiology, pathology)
• Humans
• Male
• Mycobacterium tuberculosis (genetics, isolation & purification)
• Polymerase Chain Reaction
• Tuberculosis, Cutaneous (complications, microbiology, pathology)