[Hormonal contraception and benign breast disease. Evaluation of a treatment protocol for chronic mastopathy with mastalgia].

Abstract

INTRODUCTION AND AIMS:

The aim of this study was to study patients suffering from mammary nodules, fibrocystic disease and mastodynia. Having established the absence of malignant disease, the effect of EP (oestroprogestin) was evaluated in the treatment of fibrocystic disease with mastalgia.

METHODS:

From January 1990 to December 1995 a total of 1921 women underwent breast examination at the "Centro di Fisiopatologia della Mammella" in the Division of Gynecology and Obstetrics of Iseo Municipal Hospital. Subjects were aged between 9 and 84 years old. The experimental protocol included a retrospective study of a group of 89 patients suffering from chronic fibrocystic disease with mastalgia with a 3-month follow-up. The clinical examination was commenced by recording the patient's history and the measurement of the thickness of the gland and the evaluation of mastalgia represented important stages of the eco-clinical assessment. The setting for the study was the breast pathology out-patient clinic of the Division of Gynecology and Obstetrics. These women regularly attended our outpatient clinics for the following reasons: depistage, mastodynia, mammary secretion, self-diagnosis of mammary nodules, checkups in patients during follow-up after surgery for genital neoplasia. All patients underwent clinical, echographic and often mammography/X-ray. Patients were selected on the basis of the following criteria: absence of malignant pathology and presence of chronic fibrocystic disease with mastalgia. Of those admitted to the study (no. = 89), only 59 completed the course. In addition to the absence of malignant pathology and the presence of chronic fibrocystic disease with mastalgia, the following parameters were assessed: measurement of the thickness of the mammary gland involving QSE before and after 3-month treatment with EP. The EP used were: gestodene 0.075 mg and etynylestradiol 0.03 mg-Minulet, or etynylestradiol 0.02 mg and dexogestrel 0.150 mg-Securgin and Mercilon.

RESULTS:

The response to treatment was classified according to the 4 levels of the Cardiff Breast Score (CBS). The results were relatively good: 35.59% of patients showed a reduction in symptoms; 25.42% showed a marked improvement, and 18.64% a remission of symptoms. No effect was reported in 20.33% of patients.

CONCLUSIONS:

In conclusion, it may be said that EP treatment for 3 months can at least be proposed in patients with chronic fibrocystic disease and mastalgia given that a reduction and improvement in symptoms was seen in 60% of patients.

• Authors: M Leonardi
• Journal: Minerva ginecologica (Minerva Ginecol) Vol. 49 Issue 6 Pg. 271-6 (Jun 1997) ISSN: 0026-4784 [Print] Italy
• Vernacular Title: Contraccezione ormonale e patologia mammaria benigna. Valutazione di un protocollo di trattamento nella mastopatia cronica con mastalgia.
• PMID: 9289667 (Publication Type: Journal Article)

Chemical References

• Contraceptives, Oral, Combined
• Contraceptives, Oral, Hormonal
• Estrogens
• Progesterone

Topics

• Adult
• Clinical Protocols
• Contraceptives, Oral, Combined (adverse effects)
• Contraceptives, Oral, Hormonal (adverse effects)
• Estrogens (therapeutic use)
• Female
• Fibrocystic Breast Disease (chemically induced, diagnostic imaging, drug therapy)
• Humans
• Middle Aged
• Pain (etiology)
• Progesterone (therapeutic use)
• Risk Factors
• Ultrasonography