HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cisapride in the long-term treatment of chronic gastroparesis: a 2-year open-label study.

Abstract
The effect of long-term cisapride therapy (20 mg orally three times daily for 2 years) on gastric emptying and gastrointestinal symptoms was investigated in 30 patients with severe gastroparesis (24 idiopathic, 6 diabetic). Symptoms were assessed every 2 months, using an overall symptom score based on six symptoms (anorexia, nausea, vomiting, pain, early satiety and bloating), and a 2-year mean overall symptom score was used for analysis. Gastric emptying was measured at 0, 6, 12, 18 and 24 months. Of the 24 patients who completed the study, 10 showed a significant improvement in gastric emptying (P < 0.05) and felt improved on therapy, seven patients showing a > 20% improvement in overall symptom score compared to baseline. Results for 15 patients who underwent at least one follow-up gastric-emptying test showed only a weak correlation between individual symptom score and gastric emptying (r = 0.40). Thus long-term cisapride therapy at the study dose produced long-term symptomatic improvement in 42% of patients with severe gastroparesis, with sustained acceleration of gastric emptying for up to 2 years.
AuthorsB J Kendall, E T Kendall, I Soykan, R W McCallum
JournalThe Journal of international medical research (J Int Med Res) 1997 Jul-Aug Vol. 25 Issue 4 Pg. 182-9 ISSN: 0300-0605 [Print] England
PMID9283990 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gastrointestinal Agents
  • Piperidines
  • Cisapride
Topics
  • Adult
  • Chronic Disease
  • Cisapride
  • Diabetes Complications
  • Drug Administration Schedule
  • Female
  • Gastric Emptying (drug effects)
  • Gastrointestinal Agents (administration & dosage, therapeutic use)
  • Gastroparesis (drug therapy, etiology, physiopathology)
  • Humans
  • Male
  • Patient Dropouts
  • Piperidines (administration & dosage, therapeutic use)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: