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Paradoxical expansion of intracranial tuberculomas during chemotherapy.

Abstract
A patient from India with military lung tuberculosis who developed intracranial tuberculomas under treatment with tuberculostatics is described. Computed tomography (CT) scans of the brain showed a progress of tuberculomas despite effective tuberculostatic therapy and adjunctive corticosteroid treatment. This phenomenon, termed 'paradoxical response' has rarely been reported. Continuation of chemotherapy led to improvement of brain lesions and a recovery of miliary tuberculosis. When intracranial tuberculomas develop, therapy should be continued for longer than is customary for uncomplicated tuberculosis infections. The use of steroids to suppress a 'paradoxical response' is not proven.
AuthorsM Reiser, G Fätkenheuer, V Diehl
JournalThe Journal of infection (J Infect) Vol. 35 Issue 1 Pg. 88-90 (Jul 1997) ISSN: 0163-4453 [Print] England
PMID9279735 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antitubercular Agents
  • Steroids
Topics
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Antitubercular Agents (therapeutic use)
  • Cerebral Cortex (microbiology, pathology)
  • Female
  • Humans
  • Steroids
  • Tomography, X-Ray Computed
  • Tuberculoma, Intracranial (diagnostic imaging, drug therapy, etiology)
  • Tuberculosis, Miliary (complications, drug therapy)

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