Abstract |
A patient from India with military lung tuberculosis who developed intracranial tuberculomas under treatment with tuberculostatics is described. Computed tomography (CT) scans of the brain showed a progress of tuberculomas despite effective tuberculostatic therapy and adjunctive corticosteroid treatment. This phenomenon, termed 'paradoxical response' has rarely been reported. Continuation of chemotherapy led to improvement of brain lesions and a recovery of miliary tuberculosis. When intracranial tuberculomas develop, therapy should be continued for longer than is customary for uncomplicated tuberculosis infections. The use of steroids to suppress a 'paradoxical response' is not proven.
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Authors | M Reiser, G Fätkenheuer, V Diehl |
Journal | The Journal of infection
(J Infect)
Vol. 35
Issue 1
Pg. 88-90
(Jul 1997)
ISSN: 0163-4453 [Print] England |
PMID | 9279735
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Antitubercular Agents
- Steroids
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Topics |
- Adult
- Anti-Inflammatory Agents
(therapeutic use)
- Antitubercular Agents
(therapeutic use)
- Cerebral Cortex
(microbiology, pathology)
- Female
- Humans
- Steroids
- Tomography, X-Ray Computed
- Tuberculoma, Intracranial
(diagnostic imaging, drug therapy, etiology)
- Tuberculosis, Miliary
(complications, drug therapy)
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