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Efficacy and safety of combined diclofenac 0.1% and gentamicin 0.3% eyedrops after phacoemulsification.

AbstractPURPOSE:
To study the efficacy of combined diclofenac 0.1% and gentamicin 0.3% (Digen) eyedrops to treat postoperative inflammation and prevent ocular infection in eyes having phacoemulsification.
SETTING:
Department of Ophthalmology, University of Milan, San Paolo Hospital, Milan; Eye Clinic, University of Verona; and Department of Ophthalmology, University of Palermo, Italy.
METHODS:
This double-masked, randomized, clinical trial comprised 90 patients; 45 received Digen and 45, gentamicin 0.3% eyedrops. The main outcome measure of the study was the reduction in signs and symptoms of inflammation, graded on a four-point scale. Also assessed were the presence of bacteria in the conjunctival swab and the proportion of patients requiring additional medication.
RESULTS:
Digen was more effective in reducing postoperative inflammation than gentamicin alone (P < .01). No statistically significant between-group difference was found regarding antibacterial activity. Both treatments were well tolerated throughout the study.
CONCLUSION:
Digen seemed to maintain the properties and activities of each individual drug, making it a promising treatment for reducing inflammation after phacoemulsification.
AuthorsL Rossetti, R Bellucci, S Cillino, D Monreale, L Bonomi, F Ponte, N Orzalesi
JournalJournal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 23 Issue 5 Pg. 745-9 (Jun 1997) ISSN: 0886-3350 [Print] United States
PMID9278797 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gentamicins
  • Ophthalmic Solutions
  • Diclofenac
Topics
  • Administration, Topical
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
  • Diclofenac (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Endophthalmitis (drug therapy, etiology)
  • Eye Infections, Bacterial (drug therapy, etiology)
  • Female
  • Gentamicins (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Phacoemulsification (adverse effects)
  • Retrospective Studies
  • Safety
  • Treatment Outcome

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