Abstract | PURPOSE: SETTING: Department of Ophthalmology, University of Milan, San Paolo Hospital, Milan; Eye Clinic, University of Verona; and Department of Ophthalmology, University of Palermo, Italy. METHODS: This double-masked, randomized, clinical trial comprised 90 patients; 45 received Digen and 45, gentamicin 0.3% eyedrops. The main outcome measure of the study was the reduction in signs and symptoms of inflammation, graded on a four-point scale. Also assessed were the presence of bacteria in the conjunctival swab and the proportion of patients requiring additional medication. RESULTS: Digen was more effective in reducing postoperative inflammation than gentamicin alone (P < .01). No statistically significant between-group difference was found regarding antibacterial activity. Both treatments were well tolerated throughout the study. CONCLUSION:
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Authors | L Rossetti, R Bellucci, S Cillino, D Monreale, L Bonomi, F Ponte, N Orzalesi |
Journal | Journal of cataract and refractive surgery
(J Cataract Refract Surg)
Vol. 23
Issue 5
Pg. 745-9
(Jun 1997)
ISSN: 0886-3350 [Print] United States |
PMID | 9278797
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Gentamicins
- Ophthalmic Solutions
- Diclofenac
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Topics |
- Administration, Topical
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Diclofenac
(administration & dosage, therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Endophthalmitis
(drug therapy, etiology)
- Eye Infections, Bacterial
(drug therapy, etiology)
- Female
- Gentamicins
(administration & dosage, therapeutic use)
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
- Phacoemulsification
(adverse effects)
- Retrospective Studies
- Safety
- Treatment Outcome
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