HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Ultrastructure of the tracheal epithelium in preterm neonates treated with mechanical ventilation].

Abstract
Tracheal epithelial damage, was evaluated in prematures that where intubated and with mechanical ventilation; biopsies were taken in seven preterm neonates; weight was 1100 to 2350; five were by cesarean section, y one via vaginal. Bronchial culture was negative in five, in one Lysteria monocitogena, and in another one Pseudomonas spiralis; biopsy was taken at different times o intubation. Five died because of pneumonia associated to other diseases. In optical and ultrastructural study it was found that with one day of intubation there was cilia loss; with three days of ventilation there was ciliary cells loss, and not ciliary cellular death and there were no cellular unions. In one case with three days of ventilation and 17 days of post-extubation with infection by Pseudomonas, ulcerated zones and edema were found. At 14 days there necrosis zones, increase in collagene. At 17 days there were ulcerated zones to the muscular layer with fibrosis and cellular rests at tracheal path. So, mechanical ventilation and the presence of a catheter, damage bronchial epithelium since the first 24 hours.
AuthorsH Villegas Castrejon, M Morales Juarez, O L Peralta, S Nájera Ruano, E Flores Rivera
JournalGinecologia y obstetricia de Mexico (Ginecol Obstet Mex) Vol. 65 Pg. 194-201 (May 1997) ISSN: 0300-9041 [Print] Mexico
Vernacular TitleUltraestructura del epitelio traqueal en recién nacidos pretérmino sometidos a ventilación mecánica.
PMID9273329 (Publication Type: English Abstract, Journal Article)
Topics
  • Biopsy
  • Epithelium (injuries, ultrastructure)
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intubation, Intratracheal (adverse effects)
  • Respiration, Artificial (adverse effects)
  • Trachea (injuries, ultrastructure)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: