Abstract |
A series of substances (designated CTQ compounds) with a guanidine group have been synthesized and tested for their ability to promote neuronal survival and neurite outgrowth. Mouse neuroblastoma clonal cell lines grown in serum-containing medium for 10 days as well as primary cultures of embryonic chicken ganglion neurons grown in serum-free defined medium for 1 or 2 days have been used for the experiments. Among the various CTQ compounds (CTQ1-CTQ20) tested, only CTQ8 exerted positive neurotrophic effects on these peripheral neuronal cells. At a concentration of 10(-4) M, CTQ8 enhanced neuritogenesis of neuroblastoma cells. However, the most striking influence of CTQ8 was its promoting effect (6- to 10-fold) on the survival of chicken ciliary and dorsal root ganglionic neurons at concentrations ranging from 10(-3) M to 5 x 10(-4) M.
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Authors | B Pettmann, M Escurat, C Quirosa-Guillou, C Thal, M M Portier, M Sensenbrenner |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 230
Issue 3
Pg. 167-70
(Jul 25 1997)
ISSN: 0304-3940 [Print] Ireland |
PMID | 9272687
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Guanidines
- Pyrimidines
- isaxonine
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Topics |
- Animals
- Cell Survival
(drug effects)
- Cells, Cultured
- Chick Embryo
- Ciliary Body
(cytology)
- Ganglia, Spinal
(cytology)
- Guanidines
(chemical synthesis, pharmacology)
- Mice
- Neurites
(physiology)
- Neuroblastoma
- Neurons
(cytology, drug effects, ultrastructure)
- Pyrimidines
(pharmacology)
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