HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Trophic action of pharmacological substances with a guanidine group on mouse neuroblastoma cells and chick ganglionic neurons in culture.

Abstract
A series of substances (designated CTQ compounds) with a guanidine group have been synthesized and tested for their ability to promote neuronal survival and neurite outgrowth. Mouse neuroblastoma clonal cell lines grown in serum-containing medium for 10 days as well as primary cultures of embryonic chicken ganglion neurons grown in serum-free defined medium for 1 or 2 days have been used for the experiments. Among the various CTQ compounds (CTQ1-CTQ20) tested, only CTQ8 exerted positive neurotrophic effects on these peripheral neuronal cells. At a concentration of 10(-4) M, CTQ8 enhanced neuritogenesis of neuroblastoma cells. However, the most striking influence of CTQ8 was its promoting effect (6- to 10-fold) on the survival of chicken ciliary and dorsal root ganglionic neurons at concentrations ranging from 10(-3) M to 5 x 10(-4) M.
AuthorsB Pettmann, M Escurat, C Quirosa-Guillou, C Thal, M M Portier, M Sensenbrenner
JournalNeuroscience letters (Neurosci Lett) Vol. 230 Issue 3 Pg. 167-70 (Jul 25 1997) ISSN: 0304-3940 [Print] Ireland
PMID9272687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Guanidines
  • Pyrimidines
  • isaxonine
Topics
  • Animals
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Chick Embryo
  • Ciliary Body (cytology)
  • Ganglia, Spinal (cytology)
  • Guanidines (chemical synthesis, pharmacology)
  • Mice
  • Neurites (physiology)
  • Neuroblastoma
  • Neurons (cytology, drug effects, ultrastructure)
  • Pyrimidines (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: