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A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent.

AbstractBACKGROUND:
Tinea corporis treatment usually requires topical application of an antifungal agent for 2 to 3 weeks.
OBJECTIVE:
We evaluated short-term treatment of tinea corporis with butenafine hydrochloride, a new benzylamine with in vitro fungicidal activity.
METHODS:
Patients (n = 78) were randomly selected to apply butenafine or its cream vehicle alone once daily for 14 days and were periodically assessed until day 42.
RESULTS:
Butenafine recipients had significantly higher rates of mycologic cure beginning at day 7 (64% vs 9%) with continued improvements through day 42 (88% vs 17%). They also had higher rates of effective treatment (mycologic cure and 90% to 100% symptom improvement) at day 7 (33% vs 0%) with increasing rates through day 42 (81% vs 14%).
CONCLUSION:
Butenafine provides rapid and persistent antifungal activity and symptom relief in patients with tinea corporis. Significant effects were observed within 7 days of therapy initiation, and increasing effectiveness was observed 4 weeks after therapy.
AuthorsD L Greer, J Weiss, D A Rodriguez, A A Hebert, J M Swinehart
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 37 Issue 2 Pt 1 Pg. 231-5 (Aug 1997) ISSN: 0190-9622 [Print] United States
PMID9270509 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Benzylamines
  • Naphthalenes
  • Ointments
  • butenafine
Topics
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Antifungal Agents (administration & dosage, adverse effects)
  • Benzylamines (administration & dosage, adverse effects)
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Naphthalenes (administration & dosage, adverse effects)
  • Ointments
  • Tinea (drug therapy)

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