Abstract | BACKGROUND: OBJECTIVE: METHODS: Patients (n = 78) were randomly selected to apply butenafine or its cream vehicle alone once daily for 14 days and were periodically assessed until day 42. RESULTS:
Butenafine recipients had significantly higher rates of mycologic cure beginning at day 7 (64% vs 9%) with continued improvements through day 42 (88% vs 17%). They also had higher rates of effective treatment (mycologic cure and 90% to 100% symptom improvement) at day 7 (33% vs 0%) with increasing rates through day 42 (81% vs 14%). CONCLUSION:
Butenafine provides rapid and persistent antifungal activity and symptom relief in patients with tinea corporis. Significant effects were observed within 7 days of therapy initiation, and increasing effectiveness was observed 4 weeks after therapy.
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Authors | D L Greer, J Weiss, D A Rodriguez, A A Hebert, J M Swinehart |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 37
Issue 2 Pt 1
Pg. 231-5
(Aug 1997)
ISSN: 0190-9622 [Print] United States |
PMID | 9270509
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Benzylamines
- Naphthalenes
- Ointments
- butenafine
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Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Antifungal Agents
(administration & dosage, adverse effects)
- Benzylamines
(administration & dosage, adverse effects)
- Drug Administration Schedule
- Female
- Humans
- Male
- Naphthalenes
(administration & dosage, adverse effects)
- Ointments
- Tinea
(drug therapy)
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