Abstract | STUDY OBJECTIVES: DESIGN: Prospective, nonrandomized, controlled study of consecutive hospital admissions. SETTING: Toxicology ICU in a university hospital. PATIENTS OR PARTICIPANTS: INTERVENTIONS: Distal protected catheter sampling per fiberoptic bronchoscopy and bacteriologic culture were employed as a standard to detect the bacterial component of suspected aspiration pneumonia. Plasma CRP concentrations, temperature, and WBC count were measured on hospital day 1. MEASUREMENTS AND RESULTS: Sixty-six patients were evaluated. Thirty-two had bacterial contamination by positive culture (> or =10(3) cfu/mL). Multiple receiver-operating characteristic (ROC) curves were used to compare each parameter for detection of infection secondary to aspiration. The ROC curve of CRP concentrations showed that a CRP >75 mg/L is associated with bacterial contamination with a sensitivity of 87%, specificity of 76%, positive predictive value of 78%, and negative predictive value of 87%. ROC curves of temperature and WBC count demonstrated poor diagnostic value of these markers in indicating the bacterial component of suspected aspiration pneumonia. CONCLUSIONS:
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Authors | F Adnet, S W Borron, E Vicaut, V Giraudeaux, F Lapostolle, R Bekka, F J Baud |
Journal | Chest
(Chest)
Vol. 112
Issue 2
Pg. 466-71
(Aug 1997)
ISSN: 0012-3692 [Print] United States |
PMID | 9266885
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Body Temperature
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Female
- Humans
- Leukocyte Count
- Male
- Pneumonia, Aspiration
(blood, chemically induced, complications)
- Pneumonia, Bacterial
(blood, diagnosis, epidemiology, etiology)
- Poisoning
(complications)
- Predictive Value of Tests
- Prospective Studies
- ROC Curve
- Sensitivity and Specificity
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