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(-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease.

Abstract
We have studied the effects of two D2 dopamine receptor-selective compounds, (-)-OSU 6162 and raclopride, on levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned common marmosets (Callithrix jacchus). Three monkeys developed a severe parkinsonian syndrome following administration of MPTP. In response to daily levodopa treatment the animals developed reproducible and idiosyncratic peak-dose dyskinesias. Pretreatment with (-)-OSU 6162 and raclopride, in doses increased by multiples of three, both dose-dependently relieved the levodopa-induced dyskinesias. However, in contrast to when raclopride pretreatment was given, (-)-OSU 6162 pretreatment did not induce akinesia. Our investigation suggests that (-)-OSU 6162 may be useful an an adjuvant treatment to levodopa in advanced Parkinson's disease to selectively combat levodopa-induced dyskinesias without affecting the antiparkinsonian response.
AuthorsA Ekesbo, P E Andrén, L M Gunne, J Tedroff
JournalNeuroreport (Neuroreport) Vol. 8 Issue 11 Pg. 2567-70 (Jul 28 1997) ISSN: 0959-4965 [Print] England
PMID9261828 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dopamine Antagonists
  • Piperidines
  • Salicylamides
  • OSU 6162
  • Raclopride
  • Levodopa
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Carbidopa
Topics
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Callithrix
  • Carbidopa (therapeutic use)
  • Dopamine Antagonists (pharmacology)
  • Levodopa (adverse effects, antagonists & inhibitors)
  • Male
  • Motor Activity (drug effects)
  • Parkinson Disease, Secondary (chemically induced, drug therapy, physiopathology)
  • Piperidines (pharmacology)
  • Posture
  • Raclopride
  • Salicylamides (pharmacology)

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