Proliferative potentials of glioma cells and vascular components determined with monoclonal antibody MIB-1.

Abstract

Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than that of astrocytoma (1.2 +/- 0.4, < 0.01), and lower than that of glioblastoma multiforme (12.0 +/- 5.6, < 0.05). We then compared PTC-PI values with the prognosis of patients with malignant glioma (both glioblastoma and anaplastic astrocytoma). Kaplan-Meier survival rate analysis demonstrated higher survival rates in patients with less than 8.0% of PTC-PI at 5 and 10 years (p < 0.05). These results suggested PTC-PI provides useful information which may allow better assessment of the biological behaviour and clinical prognosis of glioma, in addition to histological grading. While the average PEC-PI value (3.3) was lower than that of PTC-PI (7.0), there was a significantly close relationship between them (p < 0.01), fostering the developments novel therapies directed towards suppression of microvascular regeneration.

• Authors: X Di, T Nishizaki, K Harada, K Kajiwara, H Nakayama, H Ito
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 16 Issue 2 Pg. 153-7 (Jun 1997) ISSN: 0392-9078 [Print] England
• PMID: 9261740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal

Topics

• Antibodies, Monoclonal
• Astrocytoma (blood supply, pathology)
• Brain Neoplasms (blood supply, pathology)
• Cell Division (physiology)
• Endothelium, Vascular (cytology)
• Glioblastoma (blood supply, pathology)
• Glioma (blood supply, pathology)
• Humans
• Immunohistochemistry
• Neovascularization, Pathologic (pathology)
• Prognosis