Abstract | PURPOSE: METHODS: A soft contact lens wearer presented with an infectious keratitis. Cultures from the cornea grew N. asteroides. The infection resolved with the treatment with PHMB 0.02%. Serial dilutions of PHMB were performed against N. asteroides in culture. RESULTS: In vitro dilution studies determined that the minimal inhibitory concentration for PHMB against the tested isolate of N. asteroides was 0.01%. This is a concentration that has been shown to be well tolerated by the cornea in vivo. CONCLUSIONS:
Polyhexamethylene biguanide is effective against both Acanthamoeba and Nocardia and may have a wider range of usefulness than that currently recognized. Further testing, both in vitro and in vivo, is required.
|
Authors | J C Lin, T P Ward, D A Belyea, P McEvoy, K K Kramer |
Journal | Ophthalmology
(Ophthalmology)
Vol. 104
Issue 8
Pg. 1306-11
(Aug 1997)
ISSN: 0161-6420 [Print] United States |
PMID | 9261318
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
|
Topics |
- Adolescent
- Biguanides
(therapeutic use)
- Dose-Response Relationship, Drug
- Humans
- Keratitis
(microbiology, pathology)
- Male
- Microbial Sensitivity Tests
- Nocardia Infections
(drug therapy)
- Nocardia asteroides
- Osmolar Concentration
|