Abstract | OBJECTIVE: CLINICAL PRESENTATION: The pain syndrome of this 56-year-old woman had lasted for approximately 7 years and was localized to the posterior pharynx, tonsillar region, and base of the tongue, with radiation to the left deep ear structures. Pain was provoked by swallowing. INTERVENTION: It was first determined in a double-blind experiment that intravenous ketamine markedly reduced pain. The optimal oral dose (60 mg administered six times/d) was observed in an open dose escalating trial. In an N of 1 trial, the patient received double blindly either oral ketamine (60 mg administered six times/d) or placebo during 10 2-day periods. Ketamine caused marked pain relief, as shown by statistically significant pain relief and reduction of pain intensity. Pain caused by swallowing also was reduced by ketamine. Pain relief was associated with some side effects; however, the treatment was well tolerated by the patient. CONCLUSION:
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Authors | P K Eide, A Stubhaug |
Journal | Neurosurgery
(Neurosurgery)
Vol. 41
Issue 2
Pg. 505-8
(Aug 1997)
ISSN: 0148-396X [Print] United States |
PMID | 9257324
(Publication Type: Case Reports, Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Receptors, N-Methyl-D-Aspartate
- Ketamine
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Topics |
- Deglutition
- Double-Blind Method
- Excitatory Amino Acid Antagonists
(therapeutic use)
- Female
- Glossopharyngeal Nerve
(metabolism)
- Humans
- Ketamine
(therapeutic use)
- Middle Aged
- Neuralgia
(drug therapy, metabolism, physiopathology)
- Palliative Care
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors)
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