Comparison of an improved AFP kit with the intra-amniotic PSP dye-injection method in equivocal cases of preterm premature rupture of the fetal membranes.

Abstract

OBJECTIVE:

We developed an improved AFP kit for detecting AFP in leaked amniotic fluid. We studied the relationship between the results of the improved AFP kit and those of the intra-amniotic PSP dye-injection test (PSP test), and compared the results of two tests with the prognosis for subsequent pregnancy outcome, in order to know the diagnostic value of the two tests for preterm PROM, especially in equivocal cases.

METHODS:

We compared the results of the AFP kit test with those of the PSP test in 8 equivocal cases of preterm PROM (18th to 34th weeks of gestation).

RESULTS:

The results of the AFP kit test coincided with those of the PSP test in all 8 equivocal cases of preterm PROM. The 4 cases that tested positive resulted in preterm deliveries; and the other 4 cases that tested negative resulted in full-term deliveries.

CONCLUSION:

The use of the AFP kit test is useful in assessing the prognosis for subsequent pregnancy in equivocal cases of preterm PROM. The rapid and accurate AFP kit test for diagnosing preterm PROM can be substituted for the PSP test in bedside and outpatient-clinic assessments.

• Authors: H Yamada, T Kishida, H Negishi, T Sagawa, M Yamaguchi, C Sato, I Nakamura, H Sato, K Sakai, T Yamaguchi, S Fujimoto
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 23 Issue 3 Pg. 307-11 (Jun 1997) ISSN: 1341-8076 [Print] Australia
• PMID: 9255047 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Coloring Agents
• Reagent Kits, Diagnostic
• alpha-Fetoproteins
• Phenolsulfonphthalein

Topics

• Adult
• Amniotic Fluid (chemistry)
• Coloring Agents
• Female
• Fetal Membranes, Premature Rupture (diagnosis)
• Fetal Organ Maturity
• Gestational Age
• Humans
• Lung (embryology)
• Phenolsulfonphthalein
• Pregnancy
• Reagent Kits, Diagnostic
• alpha-Fetoproteins (analysis)