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Studies on in vivo antitussive activity of Leucas lavandulaefolia using a cough model induced by sulfur dioxide gas in mice.

Abstract
The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg), a prototype antitussive agent. The Leucas lavandulaefolia extract at 100, 200, and 400 mg/kg. p.o. showed inhibition of cough by 35.0, 51.9, and 56.5% within 1 h of performing the experiment.
AuthorsK Saha, P K Mukherjee, T Murugesan, B P Saha, M Pal
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 57 Issue 2 Pg. 89-92 (Jul 1997) ISSN: 0378-8741 [Print] Ireland
PMID9254111 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antitussive Agents
  • Sulfur Dioxide
  • Codeine
Topics
  • Animals
  • Antitussive Agents (therapeutic use)
  • Codeine (therapeutic use)
  • Cough (chemically induced, drug therapy)
  • Disease Models, Animal
  • Female
  • Male
  • Mice
  • Plants, Medicinal (chemistry)
  • Sulfur Dioxide (toxicity)

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