Abstract |
The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg), a prototype antitussive agent. The Leucas lavandulaefolia extract at 100, 200, and 400 mg/kg. p.o. showed inhibition of cough by 35.0, 51.9, and 56.5% within 1 h of performing the experiment.
|
Authors | K Saha, P K Mukherjee, T Murugesan, B P Saha, M Pal |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 57
Issue 2
Pg. 89-92
(Jul 1997)
ISSN: 0378-8741 [Print] Ireland |
PMID | 9254111
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antitussive Agents
- Sulfur Dioxide
- Codeine
|
Topics |
- Animals
- Antitussive Agents
(therapeutic use)
- Codeine
(therapeutic use)
- Cough
(chemically induced, drug therapy)
- Disease Models, Animal
- Female
- Male
- Mice
- Plants, Medicinal
(chemistry)
- Sulfur Dioxide
(toxicity)
|