HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

An updated meta-analysis of formaldehyde exposure and upper respiratory tract cancers.

Abstract
In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasopharynx. Our analyses indicate that workers with formaldehyde exposure have essentially null findings for lung cancer and a slight deficit of sinonasal cancer. Nasopharyngeal cancer rates were elevated moderately in a minority of studies. Most studies, however, did not find any nasopharyngeal cancers, and many failed to report their findings. After correcting for underreporting, we found a meta relative risk of 1.0 for cohort studies. Case-control studies had a meta relative risk of 1.3. Our review of the exposure literature indicated that the nasopharyngeal cancer case-control studies represented much lower and less certain exposures than the cohort studies. We conclude that the available studies do not support a causal relation between formaldehyde exposure and nasopharyngeal cancer. This conclusion conflicts with conclusions from two previous meta-analyses, primarily because of our consideration of unreported data.
AuthorsJ J Collins, J F Acquavella, N A Esmen
JournalJournal of occupational and environmental medicine / American College of Occupational and Environmental Medicine (J Occup Environ Med) Vol. 39 Issue 7 Pg. 639-51 (Jul 1997) ISSN: 1076-2752 [Print] UNITED STATES
PMID9253725 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens, Environmental
  • Formaldehyde
Topics
  • Carcinogens, Environmental (adverse effects)
  • Female
  • Formaldehyde (adverse effects)
  • Humans
  • Male
  • Occupational Diseases (chemically induced, epidemiology)
  • Respiratory Tract Neoplasms (chemically induced, epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: