Abstract | PURPOSE: MATERIALS AND METHODS: Patients with chemotherapy-induced neutropenia (< 1 x 10(9)/L) were divided into two groups: control group (n = 13) and rhG-CSF administration group (n = 16). rhG-CSF was administered subcutaneously at a dose of 75 micrograms/day on consecutive days. Peripheral blood cell counts and oral complications were investigated in each group. RESULTS: The duration of neutropenia and absolute neutrophil nadir counts were significantly improved by administration of G-CSF. No consistent effect on thrombocytopenia was noted. Administration of rhG-CSF also reduced the duration and degree of oral complications associated with chemotherapy-induced neutropenia. Intolerable side effects associated with administration of rhG-CSF were not observed. CONCLUSION: It was concluded that rhG-CSF is effective in shortening the duration of neutropenia after chemotherapy at a dose of 75 micrograms/day.
|
Authors | M Iwase, M Yoshiya, S Kakuta, M Nagumo |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 55
Issue 8
Pg. 836-40; discussion 841
(Aug 1997)
ISSN: 0278-2391 [Print] United States |
PMID | 9251612
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
|
Chemical References |
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Female
- Granulocyte Colony-Stimulating Factor
(administration & dosage, adverse effects)
- Humans
- Injections, Subcutaneous
- Leukocyte Count
(drug effects)
- Leukopenia
(blood, chemically induced, drug therapy)
- Male
- Middle Aged
- Mouth Mucosa
(drug effects)
- Mouth Neoplasms
(blood, complications, drug therapy)
- Neutropenia
(blood, chemically induced, drug therapy)
- Recombinant Proteins
- Stomatitis
(chemically induced)
|