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Clinical trial of recombinant granulocyte colony-stimulating factor for chemotherapy-induced neutropenia patients with oral cancer.

AbstractPURPOSE:
This study was undertaken to evaluate the efficacy and toxicity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in reducing neutropenia in patients with oral cancer undergoing intensive chemotherapy.
MATERIALS AND METHODS:
Patients with chemotherapy-induced neutropenia (< 1 x 10(9)/L) were divided into two groups: control group (n = 13) and rhG-CSF administration group (n = 16). rhG-CSF was administered subcutaneously at a dose of 75 micrograms/day on consecutive days. Peripheral blood cell counts and oral complications were investigated in each group.
RESULTS:
The duration of neutropenia and absolute neutrophil nadir counts were significantly improved by administration of G-CSF. No consistent effect on thrombocytopenia was noted. Administration of rhG-CSF also reduced the duration and degree of oral complications associated with chemotherapy-induced neutropenia. Intolerable side effects associated with administration of rhG-CSF were not observed.
CONCLUSION:
It was concluded that rhG-CSF is effective in shortening the duration of neutropenia after chemotherapy at a dose of 75 micrograms/day.
AuthorsM Iwase, M Yoshiya, S Kakuta, M Nagumo
JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 55 Issue 8 Pg. 836-40; discussion 841 (Aug 1997) ISSN: 0278-2391 [Print] United States
PMID9251612 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Female
  • Granulocyte Colony-Stimulating Factor (administration & dosage, adverse effects)
  • Humans
  • Injections, Subcutaneous
  • Leukocyte Count (drug effects)
  • Leukopenia (blood, chemically induced, drug therapy)
  • Male
  • Middle Aged
  • Mouth Mucosa (drug effects)
  • Mouth Neoplasms (blood, complications, drug therapy)
  • Neutropenia (blood, chemically induced, drug therapy)
  • Recombinant Proteins
  • Stomatitis (chemically induced)

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