Abstract | BACKGROUND: METHODS: RESULTS: In patients who had Whipple's procedure, the gastric transit time of ECPMs and of the pancake meal was not significantly different. The outcome of the indirect pancreatic function tests during enzyme supplementation was comparable, and not significantly different, from that in healthy volunteers. In patients who had PPPD, however, the gastric transit time of microspheres was greatly delayed compared with that of the pancake meal (P < 0.05). Improvement in the outcome of the indirect pancreatic function tests during enzyme supplementation was much less and remained well below that of healthy volunteers (P < 0.05). CONCLUSION: In cases of exocrine pancreatic insufficiency after Whipple's procedure, 2-mm ECPM treatment adequately restores pancreatic enzyme activity. Following PPPD, however, ECPM treatment is often ineffective because the microspheres are retained in the stomach. In these patients, use of conventional powdered pancreatin enzyme preparations may improve the efficacy of treatment.
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Authors | M J Bruno, J J Borm, F J Hoek, B Delzenne, A F Hofmann, J J de Goeij, E A van Royen, T M van Gulik, L T de Wit, D J Gouma, D J van Leeuwen, G N Tytgat |
Journal | The British journal of surgery
(Br J Surg)
Vol. 84
Issue 7
Pg. 952-6
(Jul 1997)
ISSN: 0007-1323 [Print] England |
PMID | 9240133
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol Esters
- Gastrointestinal Agents
- para-Aminobenzoates
- cholesteryl octanoate
- bentiromide
- Pancreatin
- 4-Aminobenzoic Acid
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Topics |
- 4-Aminobenzoic Acid
(metabolism)
- Aged
- Breath Tests
- Cholesterol Esters
(metabolism)
- Exocrine Pancreatic Insufficiency
(enzymology, therapy)
- Female
- Gastrointestinal Agents
(administration & dosage, pharmacokinetics)
- Gastrointestinal Transit
- Humans
- Male
- Microspheres
- Middle Aged
- Pancreaticoduodenectomy
(methods)
- Pancreatin
(administration & dosage, pharmacokinetics)
- para-Aminobenzoates
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