Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung.

Abstract

Highly alpha 2-8-sialylated N-CAM (neural cell adhesion molecule) impairs N-CAM-mediated cell adhesion. We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). These data support the hypothesis that loss of cell-cell adhesion properties might be a relevant factor in the origin of the aggressivity of lung neuroendocrine tumours.

• Authors: C Patriarca, G Pruneri, R M Alfano, N Carboni, L Ermellino, F Guddo, R Buffa, A G Siccardi, G Coggi
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 430 Issue 6 Pg. 455-60 (Jun 1997) ISSN: 0945-6317 [Print] Germany
• PMID: 9230910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• CHGA protein, human
• Chromogranin A
• Chromogranins
• Neural Cell Adhesion Molecules
• Proteins

Topics

• Antibodies, Monoclonal
• Chromogranin A
• Chromogranins (analysis)
• Humans
• Lung Neoplasms (chemistry, pathology)
• Neural Cell Adhesion Molecules (analysis, metabolism)
• Neuroendocrine Tumors (chemistry, pathology)
• Proteins (analysis)
• Up-Regulation