Familial congenital complete heart block and maternal systemic lupus erythematosis.

Abstract

A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A review of the literature on familial complete heart block suggests that so-called pure congenital-onset familial heart block, originally felt to be genetic, may in fact have an important enivronmental component, specifically related to ongoing maternal factors such as systemic lupus erythematosis.

• Authors: R B Winkler, A H Nora, J J Nora
• Journal: Circulation (Circulation) Vol. 56 Issue 6 Pg. 1103-7 (Dec 1977) ISSN: 0009-7322 [Print] United States
• PMID: 923050 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adult
• Female
• Heart Block (congenital)
• Heart Conduction System (pathology)
• Humans
• Infant, Newborn
• Lupus Erythematosus, Systemic (congenital)
• Male
• Middle Aged
• Pedigree