Abstract |
We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin - foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
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Authors | A A Barquero, S M Villamil |
Journal | Revista Argentina de microbiologia
(Rev Argent Microbiol)
1997 Jan-Mar
Vol. 29
Issue 1
Pg. 32-7
ISSN: 0325-7541 [Print] Argentina |
Vernacular Title | Estudio de la acción combinada de meliacina y foscarnet contra distintas cepas del virus herpes simplex tipo 1 empleando un modelo tridimensional. |
PMID | 9229723
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antiviral Agents
- Peptides
- Plant Proteins
- meliacin
- Foscarnet
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Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Cell Survival
(drug effects)
- Chlorocebus aethiops
- Drug Resistance, Microbial
- Drug Synergism
- Foscarnet
(pharmacology)
- Peptides
- Plant Proteins
- Simplexvirus
(classification, drug effects, physiology)
- Species Specificity
- Vero Cells
(drug effects)
- Virus Replication
(drug effects)
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