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[Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model].

Abstract
We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
AuthorsA A Barquero, S M Villamil
JournalRevista Argentina de microbiologia (Rev Argent Microbiol) 1997 Jan-Mar Vol. 29 Issue 1 Pg. 32-7 ISSN: 0325-7541 [Print] Argentina
Vernacular TitleEstudio de la acción combinada de meliacina y foscarnet contra distintas cepas del virus herpes simplex tipo 1 empleando un modelo tridimensional.
PMID9229723 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antiviral Agents
  • Peptides
  • Plant Proteins
  • meliacin
  • Foscarnet
Topics
  • Animals
  • Antiviral Agents (pharmacology)
  • Cell Survival (drug effects)
  • Chlorocebus aethiops
  • Drug Resistance, Microbial
  • Drug Synergism
  • Foscarnet (pharmacology)
  • Peptides
  • Plant Proteins
  • Simplexvirus (classification, drug effects, physiology)
  • Species Specificity
  • Vero Cells (drug effects)
  • Virus Replication (drug effects)

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